A mild, general, and metal-free method for site-specific deuteration induced by visible light using D2O as the source of deuterium atoms. Issue 3 (27th January 2020)

• Record Type: Journal Article
• Authors: Shi, Shuai; Li, Ruining; Rao, Liangming; Sun, Zhankui
• Is Part Of: Green chemistry. Volume 22:Issue 3(2020)
• Page Start: 669
• Page End: 672
• Publication Date: 2020-01-27
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc04096j
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Visible light induced desulfurization–deuteration method was developed using D2 O as the source of deuterium atoms. This radical approach features mild conditions, broad substrate scope, highly efficient D-incorporation and excellent functional group compatibility. Abstract : A radical deuteration procedure using D2 O as the source of deuterium atoms is strongly preferred in terms of mildness, sustainability, and cost. Herein, we disclose a radical approach for site-specific, highly efficient and metal-free deuteration using D2 O under visible light conditions. This desulfurization–deuteration strategy features mild conditions, broad substrate scope, highly efficient D-incorporation, excellent functional group compatibility, sustainable energy and is hardly affected by substrate steric factors.