Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction. Issue 3 (8th January 2020)

• Record Type: Journal Article
• Authors: Mwansa, Joseph M.; Page, Michael I.
• Is Part Of: Catalysis science & technology. Volume 10:Issue 3(2020)
• Page Start: 590
• Page End: 612
• Publication Date: 2020-01-08
• Subjects: Catalysis -- Periodicals; 541.395
• DOI: 10.1039/c9cy02147g
• Languages: English
• ISSNs: 2044-4753

Abstract

Abstract : The synthesis of chiral molecules is of great importance to the pharmaceutical, agrochemical, flavour and fragrance industries. Abstract : The synthesis of chiral molecules is of great importance to the pharmaceutical, agrochemical, flavour and fragrance industries. The use of organo-iridium complexes has gained a reputation for its great utility in key enantioselective synthetic procedures. Prime examples include the catalytic reduction of carbonyls and imines; iridium-catalysed allylic substitution and catalysed enantioselective hydrogenation of unsaturated carboxylic acids. Important aspects in these processes are the reaction conditions such as the catalyst loading, metal-ion ligands, the substrate, solvent and the reaction times-all of which can affect the degree of enantioselectivity. Understanding the mechanisms of these hydrogenation/reduction reactions through kinetic and other related studies makes a vital contribution to improving catalytic efficiency.