Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak. (21st January 2020)

• Record Type: Journal Article
• Authors: Falcone, Marco; Tiseo, Giusy; Antonelli, Alberto; Giordano, Cesira; Di Pilato, Vincenzo; Bertolucci, Pietro; Parisio, Eva Maria; Leonildi, Alessandro; Aiezza, Noemi; Baccani, Ilaria; Tagliaferri, Enrico; Righi, Lorenzo; Forni, Silvia; Sani, Spartaco; Mechi, Maria Teresa; Pieralli, Filippo; Barnini, Simona; Rossolini, Gian Maria; Menichetti, Francesco
• Is Part Of: Open forum infectious diseases. Volume 7:Number 2(2020)
• Publication Date: 2020-01-21
• Subjects: bacteremia -- carbapenem-resistant -- New Delhi metallo-β-lactamases; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa011
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.