The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica. Issue 4 (2nd October 2019)

• Record Type: Journal Article
• Authors: Ukwatta, Kushan M.; Lawrence, Jennifer L.; Wijayarathna, C. D.
• Is Part Of: Mycology. Volume 10:Issue 4(2019)
• Page Start: 222
• Page End: 228
• Publication Date: 2019-10-02
• Subjects: Endophytic fungi -- Bruguiera gymnorrhyza -- Nigrospora sphaerica -- Nigronapthaphenyl; Fungi -- Periodicals; Mycology -- Periodicals; Fungi; Mycology; Periodicals; 579.505
• DOI: 10.1080/21501203.2019.1620892
• Languages: English
• ISSNs: 2150-1203

Abstract

ABSTRACT: A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza . The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit α-glucosidase. Nigronapthaphenyl showed antibacterial activities against Bacillus subtilis TISTR 088 and Bacillus cereus TISTR 688 with MIC values of 4 and 2 μg/mL respectively. Cytotoxicity against colon cancer cell line HCT 116 was found to be an IC50 value of 9.62 ± 0.5 μM . This further showed potential anti-inflammatory activity amounting to an IC50 of 6.2 ± 0.5 μM and also α-glucosidase inhibitory activity, with an IC50 value of 6.9 ± 0.5 μM.