The Role of C1-Esterase Inhibitors in the Management of Vasogenic Edema in Glioblastoma. (30th January 2020)

• Record Type: Journal Article
• Authors: Naro, Gillian R.; Noverati, Nicholas; Craig, Timothy
• Other Names: Megarbane Bruno Academic Editor.
• Is Part Of: Case reports in medicine. Volume 2020(2020)
• Publication Date: 2020-01-30
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Case Reports; Periodicals; 610
• DOI: 10.1155/2020/7981609
• Languages: English
• ISSNs: 1687-9627

Abstract

Abstract : Glioblastoma (GB) is one of the most common adult primary brain tumors, classified as a grade IV astrocytoma and highly malignant in nature. As the tumor grows and disrupts the blood-brain barrier (BBB), vasogenic edema can result. The edema has the potential to significantly contribute to a patient's morbidity and mortality. Bradykinin has been theorized to play a role in this process as well as encourage tumor spread. Here we discuss a case in which a patient with vasogenic edema and angioedema refractory to antihistamines and high dose corticosteroids responded to C1-esterase inhibitor (C1INH) therapy. Though data exist concerning the role of bradykinin in GB, no clinical studies using C1INH have been done in humans with GB.