Acute Effects of Triathlon Race on Oxidative Stress Biomarkers. (17th January 2020)

• Record Type: Journal Article
• Authors: Mrakic-Sposta, Simona; Gussoni, Maristella; Vezzoli, Alessandra; Dellanoce, Cinzia; Comassi, Mario; Giardini, Guido; Bruno, Rosa Maria; Montorsi, Michela; Corciu, Anca; Greco, Fulvia; Pratali, Lorenza
• Other Names: Iuliano Luigi Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2020(2020)
• Publication Date: 2020-01-17
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2020/3062807
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : The response to strenuous exercise was investigated by reactive oxygen species (ROS) production, oxidative damage, thiol redox status, and inflammation assessments in 32 enrolled triathlon athletes (41.9 ± 7.9 yrs) during Ironman® (IR), or half Ironman® (HIR) competition. In biological samples, inflammatory cytokines, aminothiols (glutathione (GSH), homocysteine (Hcy), cysteine (Cys), and cysteinylglycine (CysGly)), creatinine and neopterin, oxidative stress (OxS) biomarkers (protein carbonyl (PC), thiobarbituric acid-reactive substances (TBARS)), and ROS were assessed. Thirteen HIR and fourteen IR athletes finished the race. Postrace, ROS (HIR +20%; IR +28%; p < 0.0001 ), TBARS (HIR +57%; IR +101%), PC (HIR +101%; IR +130%) and urinary neopterin (HIR +19%, IR +27%) significantly (range p < 0.05 -0.0001) increased. Moreover, HIR showed an increase in total Cys +28%, while IR showed total aminothiols, Cys, Hcy, CysGly, and GSH increase by +48, +30, +58, and +158%, respectively (range p < 0.05 -0.0001). ROS production was significantly correlated with TBARS and PC (R 2 = 0.38 and R 2 = 0.40 ; p < 0.0001 ) and aminothiols levels (range R 2 = 0.17 -0.47; range p < 0.01 -0.0001). In particular, ROS was directly correlated with the athletes' age (R 2 = 0.19 ; p < 0.05 ), with ultraendurance years of training (R 2 = 0.18 ; p < 0.05 ) and the days/week training activity (R 2 = 0.16 ; p < 0.05 ). Finally, the days/week training activity (hours/in the last 2 weeks) was found inversely correlated with the IL-6 postrace (R 2 = ‐ 0.21 ; p < 0.01 ). A strenuous performance, the Ironman® distance triathlon competition, alters the oxidant/antioxidant balance through a great OxS response that is directly correlated to the inflammatory parameters; furthermore, the obtained data suggest that an appropriate training time has to be selected in order to achieve the lowest ROS production and IL-6 concentration at the same time.