Effects of mechanobiological signaling in bone marrow on skeletal health. Issue 1 (11th September 2019)

• Record Type: Journal Article
• Authors: Curtis, Kimberly J.; Oberman, Alyssa G.; Niebur, Glen L.
• Editors: Sun, Hui B.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1460:Issue 1(2020)
• Page Start: 11
• Page End: 24
• Publication Date: 2019-09-11
• Subjects: mechanobiology -- bone marrow -- bone adaptation -- trabecular bone; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.14232
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: Bone marrow is a cellular tissue that forms within the pore space and hollow diaphysis of bones. As a tissue, its primary function is to support the hematopoietic progenitor cells that maintain the populations of both erythroid and myeloid lineage cells in the bone marrow, making it an essential element of normal mammalian physiology. However, bone's primary function is load bearing, and deformations induced by external forces are transmitted to the encapsulated marrow. Understanding the effects of these mechanical inputs on marrow function and adaptation requires knowledge of the material behavior of the marrow at multiple scales, the loads that are applied, and the mechanobiology of the cells. This paper reviews the current state of knowledge of each of these factors. Characterization of the marrow mechanical environment and its role in skeletal health and other marrow functions remains incomplete, but research on the topic is increasing, driven by interest in skeletal adaptation and the mechanobiology of cancer metastasis. Abstract : This review summarizes recent work related to mechanotransduction in bone marrow and its role in normal bone physiology. The authors discuss the evolution in the measurement methods and theoretical description of the mechanical properties of bone marrow, mechanisms by which bone marrow cells may be subjected to mechanical stimuli during normal vertebrate locomotion, and how these stimuli are known to affect aspects of skeletal health.