Association of Serum YKL-40 With the Presence and Severity of Obstructive Sleep Apnea Syndrome. Issue 3 (21st September 2015)

• Record Type: Journal Article
• Authors: Li, Wei; Yu, Zhen; Jiang, Chengcheng
• Is Part Of: Laboratory medicine. Volume 45:Issue 3(2014)
• Page Start: 220
• Page End: 225
• Publication Date: 2015-09-21
• Subjects: YKL-40 -- inflammation -- obstructive sleep apnea syndrome -- severity; Clinical chemistry -- Periodicals; Pathology -- Periodicals; Medical technology -- Periodicals; Chemistry, Clinical; Pathology; Medical Laboratory Science; Clinical chemistry; Medical technology; Pathology; Electronic journals; Periodicals; Periodicals; 616
• DOI: 10.1309/LMS98AKCXRSL2XOR
• Languages: English
• ISSNs: 0007-5027

Abstract

Abstract : Objective: This study examined the association of serum YKL-40 concentrations with the presence and severity of obstructive sleep apnea syndrome (OSAS). Methods: A total of 156 patients with OSAS and 110 healthy subjects were enrolled in this study. Results: OSAS patients had significantly higher serum YKL-40 levels compared with healthy controls. Multivariable logistic regression analysis indicated that serum YKL-40 levels were an independent determinant of the presence of OSAS. Serum YKL-40 levels were significantly elevated in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis revealed that serum YKL-40 levels were correlated with the severity of OSAS. Simple linear regression analysis showed that the serum levels of YKL-40 were correlated with body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and apnea-hypopnea index (AHI) in patients with OSAS. Conclusion: Elevated serum YKL-40 levels are associated with the presence and severity of OSAS.