Monolithic Silica Support for Immobilized Catalysis in Continuous Flow. Issue 2 (5th December 2019)

• Record Type: Journal Article
• Authors: Russell, M. Grace; Veryser, Cedrick; Hunter, James F.; Beingessner, Rachel L.; Jamison, Timothy F.
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 2(2020)
• Page Start: 314
• Page End: 319
• Publication Date: 2019-12-05
• Subjects: continuous flow -- heterogeneous catalysis -- hydrogenation -- immobilization -- organocatalysis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201901185
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Monolithic and packed‐bed reactors featuring immobilized catalysts are well‐precedented in continuous flow synthesis but can suffer from adverse pressure drops during use due to their small pore sizes and/or structural changes. Herein, we overcome this challenge with the synthesis of a structurally robust silica‐based monolith featuring pore sizes on the millimeter scale. The 3‐dimensional solid support structure is constructed from a polystyrene foam‐based template and features a functional group handle that can be modified to display a reactive catalyst. Here we functionalize the support with palladium(0) for hydrogenation reactions and a modified proline catalyst for the alpha functionalization of aldehydes. Both reactors showed good activity and excellent catalytic longevity when utilized under continuous flow conditions. Abstract :