Insight into adipokines to optimize therapeutic effects of stem cell for tissue regeneration. (April 2020)

• Record Type: Journal Article
• Authors: Mohammadi, Chiman; Sameri, Saba; Najafi, Rezvan
• Is Part Of: Cytokine. Volume 128(2020)
• Publication Date: 2020-04
• Subjects: ALP alkaline phosphatase -- ALPM anterior lateral plate mesoderm -- AMI acute myocardial infarction -- APJ apelin receptor -- Aplnr apelin receptor -- BMD bone mineral density -- BMSCs bone marrow-derived mesenchymal stem cells -- CSCs cardiac stem cells -- DPSCs dental pulp stem cells -- EBs embryonic bodies -- ECs endothelial cells -- ELA ELABELA -- EPCs endothelial progenitor cells -- EPO erythropoietin -- ES embryonic stem cells -- grn grinch -- G-CSF granulocyte colony stimulating factor -- hATSCs human adipose tissue-derived mesenchymal stem cells -- HF heart failure -- HGF hepatocyte growth factor -- HIF-1α hypoxia-inducible factor -- hiPSCs human induced pluripotent stem cells -- HP hypoxic preconditioning -- HRE hypoxia-responsive element -- HSCs hematopoietic stem cells -- HSPCs hematopoietic stem/progenitor cells -- HSPs heat shock proteins -- HUVECs Human umbilical vein endothelial cells -- IGF-1 insulin-like growth factor-1 -- IL-6 interleukin-6 -- JAK Janus Kinase -- LAC Lung adenocarcinoma -- LIF leukemia inhibitory factor -- LPS lipopolysaccharide -- MAPK mitogen activated protein kinase -- MCP-1 monocyte chemotactic protein-1 -- MEFs mouse embryonic fibroblasts -- MHO metabolically healthy obese -- MI myocardial infarction -- mOSM murine OSM -- MSCs mesenchymal stem cells -- NO nitric oxide -- NSCs neural stem cells -- OCN osteocalcin -- OLETF Otsuka Long- Evans Tokushima fatty -- OSM oncostatin M -- PAI-1 plasminogen activator inhibitor-1 -- PB peripheral blood -- PI3K phosphoinositide‑3 kinase -- RBP4 retinol binding protein 4 -- ROS reactive oxygen species -- SD Sprague-Dawley -- SDF-1 stromal-derived factor-1 -- siRNA small interfering RNA -- TLR toll-like receptor -- VAT visceral adipose tissue -- VEGF vascular endothelial growth factor -- WAT white adipose tissue -- WJ-MSCs wharton's jelly-derived mesenchymal stem cells; Stem cell therapy -- Apelin -- Oncostatin M -- Omentin-1 -- Vaspin; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2020.155003
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Stem cell-based therapy has emerged as a promising strategy in clinical research to regenerate tissues in diseased organs. Preconditioning of stem cells are fundamental approaches to improve stem cells function. Adipokines play critical roles in the physiological process through the network of autocrine, paracrine, and endocrine pathways. Adipokines such as apelin, oncostatin M, omentin-1, and vaspin are protective factors for improving the survival rate and therapeutic effects of stem cells. Abstract: Stem cell therapy is considered as a promising regenerative medicine for repairing and treating damaged tissues and/or preventing various diseases. But there are still some obstacles such as low cell migration, poor stem cell engraftment and decreased cell survival that need to be overcome before transplantation. Therefore, a large body of studies has focused on improving the efficiency of stem cell therapy. For instance, preconditioning of stem cells has emerged as an effective strategy to reinforce therapeutic efficacy. Adipokines are signaling molecules, secreted by adipose tissue, which regulate a variety of biological processes in adipose tissue and other organs including the brain, liver, and muscle. In this review article, we shed light on the biological effects of some adipokines including apelin, oncostatin M, omentin-1 and vaspin on stem cell therapy and the most recent preclinical advances in our understanding of how these functions ameliorate stem cell therapy outcome.