Design and Fabrication of a PDMS-Based Manual Micro-Valve System for Microfluidic Applications. (12th January 2020)

• Record Type: Journal Article
• Authors: Le, Tu N.; Nguyen, Van-Anh; Bach, Giang L.; Tran, Lam D.; Cao, Ha H.
• Other Names: Zapotoczny Szczepan Academic Editor.
• Is Part Of: Advances in polymer technology. Volume 2020(2020)
• Publication Date: 2020-01-12
• Subjects: Plastics -- Periodicals; Polymers -- Periodicals; 668.9
• DOI: 10.1155/2020/2460212
• Languages: English
• ISSNs: 0730-6679

Abstract

Abstract : In this study, a manual micro-valve system (dimension: w × h : 1000 × 50 μ m with 8-integrated channel valves was designed for controlling up to 8 different flows of agents (including magnetic nanoparticle flow) injected into the mixture zone of the microfluidics. The working parts of the micro-valve and microfluidic channel were fabricated from Poly(dimethyl siloxane) materials. The aperture of each channel valve was manually manipulated by a screw and a support kit (made of Plexiglas® materials). This valve system was connected to a microfluidic device with two important modules: a multi-liquid mixing component and a micro-reactor (~5 μ L of volume). The study on controlling liquid flows proved that this valve system was effective for the experiments on the flow mixing and delivering the reactants into the micro-reaction chamber in order. The results are the first step for the fabrication of liquid flow controllers in integrated microfluidic systems towards biological analysis applications.