On the move: redox-dependent protein relocation in plants. (17th August 2019)

• Record Type: Journal Article
• Authors: Foyer, Christine H; Baker, Alison; Wright, Megan; Sparkes, Imogen A; Mhamdi, Amna; Schippers, Jos H M; Van Breusegem, Frank
• Editors: Dietz, Karl-Josef
• Is Part Of: Journal of experimental botany. Volume 71:Number 2(2020)
• Page Start: 620
• Page End: 631
• Publication Date: 2019-08-17
• Subjects: Catalase -- moonlighting proteins -- nitric oxide -- reactive oxygen species -- redox signaling -- stromules; Botany -- Periodicals; Botany, Experimental -- Periodicals; Plant physiology -- Periodicals; 580
• DOI: 10.1093/jxb/erz330
• Languages: English
• ISSNs: 0022-0957

Abstract

Abstract : Some proteins move between different intracellular compartments such as the cytosol or chloroplasts and the nucleus in response to redox triggers. Redox post-translational modifications control the intercompartmental switching of proteins. Abstract: Compartmentation of proteins and processes is a defining feature of eukaryotic cells. The growth and development of organisms is critically dependent on the accurate sorting of proteins within cells. The mechanisms by which cytosol-synthesized proteins are delivered to the membranes and membrane compartments have been extensively characterized. However, the protein complement of any given compartment is not precisely fixed and some proteins can move between compartments in response to metabolic or environmental triggers. The mechanisms and processes that mediate such relocation events are largely uncharacterized. Many proteins can in addition perform multiple functions, catalysing alternative reactions or performing structural, non-enzymatic functions. These alternative functions can be equally important functions in each cellular compartment. Such proteins are generally not dual-targeted proteins in the classic sense of having targeting sequences that direct de novo synthesized proteins to specific cellular locations. We propose that redox post-translational modifications (PTMs) can control the compartmentation of many such proteins, including antioxidant and/or redox-associated enzymes.