Copper-free click functionalization of glucose-derived carbon spheres for tumor targeting. (2019)

• Record Type: Journal Article
• Authors: Gessner, Isabel; Krakor, Eva; Styrnol, Sarah; Klimpel, Annika; Neundorf, Ines; Mathur, Sanjay
• Is Part Of: MRS advances. Volume 4:Number 53(2019)
• Page Start: 2881
• Page End: 2887
• Publication Date: 2019
• Subjects: biomedical, -- biomaterial, -- hydrothermal, -- surface chemistry, -- tissue; Electrical engineering -- Congresses; Physics -- Congresses; Materials -- Research -- Congresses; Materials science -- Congresses; 620.11
• DOI: 10.1557/adv.2019.488
• Languages: English
• ISSNs: 2059-8521

Abstract

Abstract: The dysfunctional metabolism of glucose in cancer cells represents a new avenue for cancer targeting based on sugar-derived carriers. Here, glucose-derived carbon spheres (CS) were prepared through a simple hydrothermal method, yielding highly homogenous spherical particles that exhibited excellent stability in aqueous solution. The abundant presence of surface hydroxyl functionalities was used for a subsequent condensation of an amino silane that was the basis for further covalent coupling strategies. CS were modified with a cyclooctyne derivative providing a highly selective binding site for copper-free click reactions. Moreover, the surface modification of CS with a dye-label allowed for their intracellular detection revealing a preferential uptake of CS, compared to silica particles, in tumor cells. These results thus demonstrate the highly promising potential of glucose-derived particles for tumor targeting applications and their efficient surface modification.