HIV Disrupts Human T Cells That Target Mycobacterial Glycolipids. (15th September 2015)

• Record Type: Journal Article
• Authors: Kasprowicz, Victoria O.; Cheng, Tan-Yun; Ndung'u, Thumbi; Sunpath, Henry; Moody, D. Branch; Kasmar, Anne G.
• Is Part Of: Journal of infectious diseases. Volume 213:Number 4(2016:Feb. 15)
• Page Start: 628
• Page End: 633
• Publication Date: 2015-09-15
• Subjects: tuberculosis -- HIV -- CD1 -- T cell -- glycolipids -- antigens -- tetramer; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiv455
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract : Single-cell analysis captures the heterogeneity of T-cell populations that target defined antigens. Human immunodeficiency virus (HIV) infection results in defects of antimycobacterial immunity, which remain poorly defined. We therefore recruited a small number of subjects, including those with latent and active M. tuberculosis infection, with or without concomitant HIV infection, and tracked the mycobacterial glycolipid-reactive T-cell repertoire by using CD1b tetramers. Glycolipid-reactive T cells expressed memory markers and the HIV coreceptors CD4 and CCR5; they were not detected in subjects with HIV-associated active M. tuberculosis infection. HIV infection may affect T cells that recognize mycobacterial glycolipids and influence immunity.