The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol. (April 2015)

• Record Type: Journal Article
• Authors: Kocher, Alexa; Schiborr, Christina; Behnam, Dariush; Frank, Jan
• Is Part Of: Journal of functional foods. Volume 14(2015)
• Page Start: 183
• Page End: 191
• Publication Date: 2015-04
• Subjects: AUC area under the plasma concentration–time curve -- BDMC bis-demethoxycurcumin -- Cmax maximum plasma concentration -- DMC demethoxycurcumin -- NC native curcuminoids -- NCP native curcuminoids and phytochemicals -- MC micellar curcuminoids -- MCP micellar curcuminoids and phytochemicals -- Tmax time to reach the maximum plasma concentration; Bioavailability -- Curcumin -- Curcuminoids -- Micelles -- Pharmacokinetics -- Phytochemicals; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.01.045
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Native curcuminoids have poor oral bioavailability. Pharmacokinetics of curcuminoid formulations were studied in healthy humans. Intake of native curcuminoids with phytochemicals slightly improves bioavailability. Micellar solubilisation increases the AUC of the lead curcuminoid curcumin 88-fold. Curcumin micelles combined with phytochemicals do not further enhance bioavailability. Abstract: Curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) are poorly absorbed and rapidly metabolised and excreted. We investigated in healthy young and aged women and men if co-administration of adjuvants (sesamin, ferulic acid, naringenin, and xanthohumol) alone or in combination with micellar solubilisation improves the bioavailability of curcuminoids. A single oral dose of 98 mg curcuminoids was administered as native curcuminoids (NC), native curcuminoids plus phytochemicals (NCP), curcuminoid micelles (MC) or curcuminoid plus phytochemical micelles (MCP). Total curcuminoids were quantified in blood samples collected over 24 h. Based on the area under the curve, NCP, MC, and MCP increased the bioavailability of the major curcuminoid curcumin 8-, 88-, and 73-fold, respectively, compared to NC. No sex or age differences were observed. Thus, simultaneous ingestion of phytochemicals does modestly increase curcuminoid bioavailability, but does not enhance the large increase in bioavailability observed with micellar curcuminoids.