Intrinsic and Miniature Postsynaptic Current Changes in Rat Principal Neurons of the Lateral Superior Olive after Unilateral Auditory Deprivation at an Early Age. (21st January 2020)

• Record Type: Journal Article
• Authors: Zhou, Mo; Yuan, Jingjing; Yan, Zhanfeng; Dai, Jinsheng; Wang, Xing; Xu, Tao; Xu, Zhiqing; Wang, Ningyu; Liu, Jinfeng
• Is Part Of: Neuroscience. Volume 428(2020)
• Page Start: 2
• Page End: 12
• Publication Date: 2020-01-21
• Subjects: ACSF artificial cerebrospinal fluid -- AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid -- AP action potential -- AVCN anteroventral cochlear nucleus -- CNQX 6-cyano-7-nitroquinoxaline-2, 3-dione -- d-APV d-2-amino-5-phosphonopentanoate -- EGTA ethylene glycol tetraacetic acid -- GABA γ-aminobutyric acid -- GluR glutamate receptor -- HEPES 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid -- IR-DIC infrared differential interference contrast -- LSO lateral superior olive -- mEPSCs miniature excitatory postsynaptic currents -- mIPSCs miniature inhibitory postsynaptic currents -- MNTB medial nucleus of the trapezoid body -- NMDA N-methyl-d-aspartate -- SD Sprague-Dawley -- TTX tetrodotoxin; lateral superior olive -- unilateral auditory deprivation -- intrinsic properties -- miniature postsynaptic currents -- cochlear ablation; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2019.12.001
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Unilateral auditory deprivation changes the membrane properties of principal neurons in the LSO on both sides. mIPSCs in principal neurons are downregulated on the intact side at one week after unilateral cochlear ablation. mEPSCs in principal neurons show compensatory effects on the ablated side at one week after unilateral cochlear ablation. Abstract: Unilateral auditory deprivation results in lateralization changes in the central auditory system, interfering with the integration of binaural information and thereby leading to a decrease in binaural auditory functions such as sound localization. Principal neurons of the lateral superior olive (LSO) are responsible for computing the interaural intensity differences that are critical for sound localization in the horizontal plane. To investigate changes caused by unilateral auditory deprivation, electrophysiological activity was recorded from LSO principal neurons in control rats and rats with unilateral cochlear ablation. At one week after unilateral cochlear ablation, the excitability of LSO principal neurons on the side ipsilateral to the ablation (the ablated side) was greater than that on the side contralateral to the ablation (the intact side); however, the input resistance increased on both sides. Furthermore, by analysing the miniature inhibitory postsynaptic currents and miniature excitatory postsynaptic currents, we found that unilateral auditory deprivation weakened the inhibitory driving force on the intact side, whereas it strengthened the excitatory driving force on the ablated side. In summary, asymmetric changes in the electrophysiological activity of LSO principal neurons were found on both sides at postnatal day 19, one week after unilateral cochlear ablation.