An efficient route for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives promoted by CBr4 in one pot. Issue 9 (28th February 2020)

• Record Type: Journal Article
• Authors: Xie, Caixia; Li, Songhua; Li, Yunyi; Ma, Chen
• Is Part Of: Tetrahedron. Volume 76:Issue 9(2020)
• Publication Date: 2020-02-28
• Subjects: CBr4 -- 1H-benzo[d]imidazol-2-amine -- Synthesis -- N-(1H-benzo[d]imidazol-2-yl)benzamide -- Atom economy; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2020.130977
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A metal-free one-pot method for the synthesis of N -(1 H -benzo[ d ]imidazol-2-yl)benzamide derivatives was proposed mediated by CBr4 . The reaction went through ring formation and opening processes with only two protons leaving and the thermodynamically favorable products were selectively formed in moderate to good yields. Graphical abstract: Image 1