Metabolomic analysis of serum using proton NMR in 6-OHDA experimental PD model and patients with PD. (March 2020)

• Record Type: Journal Article
• Authors: Kumari, Sadhana; Kumaran, S Senthil; Goyal, Vinay; Bose, Samrat; Jain, Suman; Dwivedi, Sada Nand; Srivastava, Achal Kumar; Jagannathan, Naranamangalam R
• Is Part Of: Neurochemistry international. Volume 134(2020)
• Publication Date: 2020-03
• Subjects: Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2020.104670
• Languages: English
• ISSNs: 0197-0186

Abstract

Graphical abstract: Image 1 Highlights: Identification of biomarkers are essential for the diagnosis and prognosis of PD. Serum metabolomics compared between PD patients and HC; PD model and sham control. Elevated metabolites: 6 in PD patients, 7 in experimental model; 4 common in both. A negative correlation between clinical phenotype and metabolic profile was observed. Impairment in gut microflora system and amino acids metabolism was observed.