Intra-procedural dual phase cone beam computed tomography has a better diagnostic accuracy over pre-procedural MRI and MDCT in detection and characterization of HCC in cirrhotic patients undergoing TACE procedure. Issue 124 (March 2020)

• Record Type: Journal Article
• Authors: Lucatelli, Pierleone; De Rubeis, Gianluca; Ginnani Corradini, Luca; Basilico, Fabrizio; Di Martino, Michele; Lai, Quirino; Ginanni Corradini, Stefano; Cannavale, Alessandro; Nardis, Pier Giorgio; Corona, Mario; Saba, Luca; Catalano, Carlo; Bezzi, Mario
• Is Part Of: European journal of radiology. Issue 124(2020)
• Publication Date: 2020-03
• Subjects: BCLC Barcelona Clinic Liver Cancer trans-arterial chemoembolization -- CI confidence intervals -- DP-CBCT dual phase cone beam computed tomography -- HCC hepatocellular carcinoma -- HVF hyper-vascular foci -- MDCT multidetector computed tomography -- MRI magnetic resonance imaging -- ROC received operator characteristic -- RS reference standard -- SLIM second-line imaging modalities -- TACE trans-arterial chemoembolization -- US ultra-sound; Hepatocellular cancer -- Therapeutic chemoembolization -- Cone-Beam computed tomography -- Computerized tomography, X ray -- Magnetic resonance imaging; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2019.108806
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Accuracy and NPV of DP-CBCT were higher than MDCT and MRI (94%vs78%; 92%vs30%, respectively) Confirmed HCC visible only in DP-CBCT were 54/243 (22%) Nodules' diameter was higher in DP-CBCT than MDCT and MRI (mean increase 1.6 mm; + 7.5%, p < 0.05) Abstract: Purpose: This study was directed to compare diagnostic accuracy of dual-phase cone beam computed tomography (DP-CBCT) vs pre-procedural second line imaging modality (SLIM [multidetector computed tomography and magnetic resonance imaging]) to detect and characterize hepatocellular carcinoma (HCC) in cirrhotic patients with indication for trans-arterial chemoembolization (TACE). Methods: This is a single centre, retrospective, and observational study. Exclusion criteria were not-assisted DP-CBCT TACE, and unavailable follow-up SLIM. We evaluated 280 consecutive patients (January/2015-Febraury/2019). Seventy-two patients were eligible. Three radiologists in consensus reviewed: pre-procedural SLIM, DP-CBCT, and SLIM at follow-up, with 4 months of interval between each reading. Hyper-vascular foci (HVF) were detected and characterized. Diameter was recorded. Radiological behaviour, according to LI‐RADS criteria, of HFV throughout follow-up time was the reference standard. Diagnostic accuracy was calculated for pre-procedural SLIM and DP-CBCT and evaluated through receiver operating characteristic curve. HVF only visible on DP-CBCT (defined as occult) were analysed. Tumour diameters were compared. Results: Median time between pre-procedural SLIM and DP-CBCT and between DP-CBCT and definitive radiological diagnosis of HVF were 46.0 days (95%CI 36.5–55.0) and 30.5 days (95%CI 29.0–33.0), respectively. DP-CBCT had a better diagnostic performance than pre-examination SLIM (sensitivity 99%vs78%; specificity 89%vs85%; PPV 99%vs99%; NPV 92%vs30%; and accuracy 94%vs79%). DP-CBCT diagnosed 63 occult HVF. Occult HCC were 54/243 (22.2%). Six were occult angiomas. Three were false positive. Mean diameter was significantly higher in DP-CBCT vs pre-procedural SLIM (+7.5% [95%CI 3.7–11.3], p < 0.05). Conclusions: DP-CBCT has a better diagnostic accuracy and NPV than pre-procedural SLIM in cirrhotic patients with indication for TACE.