Metacognitive impairment in patients with episodic and chronic migraine. (February 2020)

• Record Type: Journal Article
• Authors: Zucca, Milena; Rubino, Elisa; Vacca, Alessandro; De Martino, Paola; Roveta, Fausto; Govone, Flora; Gai, Annalisa; Caglio, Marcella; Gentile, Salvatore; Giordana, Maria T.; Rainero, Innocenzo
• Is Part Of: Journal of clinical neuroscience. Volume 72(2020)
• Page Start: 119
• Page End: 123
• Publication Date: 2020-02
• Subjects: Metacognition -- Executive functions -- Migraine -- Medication-overuse headache -- Wisconsin card sorting test; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2019.12.048
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Migraine patients show metacognitive control dysfunctions. Metacognitive problems appear to get worse with the presence of medication overuse. Metacognitive deficits may become a new therapeutic target in migraine patients. Abstract: Migraine is one of the most common medical disorder in the world. Metacognition is the ability to monitor one's own cognitive functioning and consequently direct one's behavior. In adult migraine patients, the neuropsychological profile has been poorly investigated, and metacognitive functions have never been assessed. The aim of the present study was therefore to evaluate executive metacognitive abilities in patients with episodic and chronic migraine. Sixty-four migraine patients (male/female = 18/46; mean age = 45.65 ± 11.61 years): 27 patients with episodic migraine without aura (male/female = 9/18; mean age ± SD = 45.11 ± 12.18 years) and 37 patients with chronic migraine and medication-overuse headache (male/female = 9/28; mean age ± SD = 46.05 ± 11.32 years) were selected for the study. Twenty-nine controls (male/female = 12/17; mean age ± SD = 42.86 ± 14.78 years) were also enrolled in the research. Metacognitive and executive skills were assessed using the metacognitive version of Wisconsin Card Sorting Test. Migraine patients exhibited a lower performance in metacognitive tasks in respect to controls in term of worse outcomes in accuracy score (p = 0.012), global monitoring (p = 0.015), monetary gains (p = 0.022), and control sensitivity (p = 0.027). A reduction in accuracy score (p = 0.001), free-choice improvement (p = 0.002), global monitoring (p = 0.003), monetary gains (p = 0.009), and control sensitivity (p < 0.001) was also found in patients with chronic migraine and medication-overuse headache in respect to patients with episodic migraine. Our study supports the hypothesis that migraine patients show metacognitive dysfunctions that become worse with the chronicization of the disease and the increase of medication use.