A BHT-regulated chemoselective access to monofluorinated chromones. Issue 8 (21st February 2020)

• Record Type: Journal Article
• Authors: Zhao, Qing-Lan; Xia, Peng-Jiu; Zheng, Lan; Xie, Zhen-Zhen; Hu, Yuan-Zhuo; Chen, Guang-Jian; Chen, Xiao-Qing; Xiang, Hao-Yue; Yang, Hua
• Is Part Of: Tetrahedron. Volume 76:Issue 8(2020)
• Publication Date: 2020-02-21
• Subjects: BHT -- Selectfluor -- Monofluorinated -- Chromone; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2019.130833
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A BHT-regulated chemoselective monofluorination of enaminones with Selectfluor under mild reaction conditions was unveiled for the first time. As a result, an array of monofluorinated chromones were efficiently assembled in a simple operational manner. Moreover, the scalability of this protocol and the versatility for the downstream transformations of the obtained fluorinated chromones to installing diverse nitrogen-containing heterocycles greatly broaden the practical applications of this developed protocol. Graphical abstract: Image 1 Highlights: A BHT-regulated chemoselective monofluorination of enaminones with Selectfluor under mild reaction conditions was unveiled for the first time. Moreover, the scalability of this protocol and the versatility for the downstream transformations of the obtained fluorinated chromones to installing diverse nitrogen-containing heterocycles greatly broaden the practical applications of this developed protocol.