Differential and quantitative neuroimaging characteristics of inclusion body myositis. (February 2020)

• Record Type: Journal Article
• Authors: Furuta, Minori; Furuta, Natsumi; Nagashima, Kazuaki; Fujita, Yukio; Tsushima, Yoshito; Ikeda, Yoshio
• Is Part Of: Journal of clinical neuroscience. Volume 72(2020)
• Page Start: 244
• Page End: 251
• Publication Date: 2020-02
• Subjects: Inclusion body myositis -- Muscular degeneration -- Neuroimaging -- Computed tomography; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2019.11.029
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: IBM cases increased in number and frequency over time. Quantitative CT analysis revealed characteristic muscular degeneration for IBM. The anterior thigh muscles were preferentially affected over the posterior muscles. CT of the lower limb muscles is useful for making the diagnosis of IBM. Abstract: In clinical settings, it is often difficult to distinguish inclusion body myositis (IBM) from other neuromuscular diseases. In order to clarify clinically useful characteristics for making the differential diagnosis of IBM, we performed clinical, epidemiological, and neuroimaging analyses in patients with various types of neuromuscular disorders. We enrolled 333 patients with myopathy and 12 patients with amyotrophic lateral sclerosis (ALS) who had been hospitalized in our department from January 1, 1979, to December 31, 2018. Among them, 18 patients with IBM, 16 patients with polymyositis (PM), and 12 patients with ALS who showed equivalent severity of muscle weakness in their lower limbs underwent the quantitative neuroimaging analysis using lower limb CT and clinical assessment. Patients with IBM exhibited significantly greater muscular degeneration in the rectus femoris, vastus, sartorius, adductor, anterior calf, and medial gastrocnemius muscles than those with PM or ALS. The ratio of the remaining muscle area of the quadriceps relative to that of the hamstrings and the duration from onset to CT imaging were negatively correlated in patients with IBM, indicating that the anterior thigh muscles were preferentially affected over the posterior muscles. Characteristic muscular degeneration in the lower limbs on CT imaging may aid for making the diagnosis of IBM.