Hepatitis B virus-associated B-cell non-Hodgkin lymphoma in non-endemic areas in Western Europe: Clinical characteristics and prognosis. Issue 2 (February 2020)

• Record Type: Journal Article
• Authors: Lemaitre, Marine; Brice, Pauline; Frigeni, Marco; Hermine, Olivier; Arcaini, Luca; Thieblemont, Catherine; Besson, Caroline
• Is Part Of: Journal of infection. Volume 80:Issue 2(2020)
• Page Start: 219
• Page End: 224
• Publication Date: 2020-02
• Subjects: Non-Hodgkin lymphoma -- Hepatitis B virus -- Outcomes; Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2019.12.005
• Languages: English
• ISSNs: 0163-4453

Abstract

Abstract : The association between B-cell non-Hodgkin lymphoma (NHL) and hepatitis B virus (HBV) is well demonstrated by epidemiological studies. Most studies concerning this association have been conducted in endemic areas. Thus, little is known concerning the clinical characteristics of HBV-related lymphomas in non-endemic areas. Here, we report the characteristics and outcomes of 39 patients with active HBV infection and B-cell NHL collected retrospectively in France and Italy. We also compared their characteristics with those of HCV-positive patients with NHL. The gender ratio (M/F) was 3.3 and the median age at NHL diagnosis, 59 years. The pathological distribution was 24 (62%) diffuse large B-cell lymphomas (DLBCLs) and 15 (38%) other lymphomas subtypes: marginal zone lymphoma ( n = 6), follicular lymphoma ( n = 3), mantle cell lymphoma ( n = 2), Burkitt's lymphoma ( n = 1), and not otherwise specified low-grade B-NHL ( n = 3). Treatment included antiviral therapy for 35 patients (90%). Twenty-two (92%) DLBCL patients received an R-CHOP or R-CHOP-like regimen, leading to complete remission for 18 (75%).At one year, 21 DLBCL patients (88%) were alive, and 13 other B-cell lymphoma patients (87%) were alive. This European study underscores the predominance of DLBCL among patients with active HBV infection and their similar outcomes to non-HBV infected patients with DLBCL when treated with R-CHOP and antivirals.