Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use. Issue 4 (4th July 2019)

• Record Type: Journal Article
• Authors: Chien, Jason L.; Baez, Valentina; Mody, Harshad R.
• Is Part Of: Journal of community hospital internal medicine perspectives. Volume 9:Issue 4(2019)
• Page Start: 371
• Page End: 372
• Publication Date: 2019-07-04
• Subjects: Gabapentin -- myasthenia gravis; Internal medicine -- Periodicals; Hospitals -- Periodicals; Hospitals, Community; Internal Medicine; Hospitals; Internal medicine; Periodicals; Periodicals; 610
• DOI: 10.1080/20009666.2019.1643220
• Languages: English
• ISSNs: 2000-9666

Abstract

ABSTRACT: Gabapentin is an anticonvulsant medication that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca2+ and Na+ channels. It is approved to treat focal seizures but also used to treat post-herpetic and neuropathic pain. Although uncommon, there have been three reported cases of myasthenia gravis exacerbation associated with gabapentin in the literature. We present a patient with uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use and provide a review for the three published cases.