KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives. Issue 4 (2nd October 2019)

• Record Type: Journal Article
• Authors: Azizi, Sajjad; Shadjou, Nasrin; Hasanzadeh, Mohammad
• Is Part Of: Nanocomposites. Volume 5:Issue 4(2019)
• Page Start: 124
• Page End: 132
• Publication Date: 2019-10-02
• Subjects: Dendritic fibrous nano-silica -- bioactive scaffold -- tetrahydrodipyrazolopyridines -- pharmaceutical compounds -- advanced functional materials; Nanocomposites (Materials) -- Periodicals; 620.11805
• DOI: 10.1080/20550324.2019.1681623
• Languages: English
• ISSNs: 2055-0324

Abstract

Abstract: In this study, a novel approach has been used for the efficient synthesis of tetrahydrodipyrazolopyridine derivatives (5a–m ) via a four-component one-pot condensation reaction of aromatic aldehydes, hydrazinehydrate, ethyl acetoacetate, and ammonium acetate in the presence of KCC-1-npr-NH2 -DPA as an advanced nano-catalyst in ethanol under reflux conditions at 30 min. For this purpose, mesoporous fibrous nano-silica functionalized by dipenicillamine as a novel nanocatalyst (KCC-1-npr-NH2 -DPA) was synthesized using a hydrothermal protocol. KCC-1-npr-NH2 -DPA nano-catalyst is easily recyclable eight times without the considerable loss of catalytic activity. Other remarkable features include the short reaction time, simple work-up procedure and providing excellent yields (89–98%) of the products under mild reaction conditions. Furthermore, the effects of solvent, concentration of catalyst, time and temperature for the synthesis of tetrahydrodipyrazolopyridine (5a ) were studied. Graphical Abstract: