Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer. (2nd November 2019)

• Record Type: Journal Article
• Authors: Castel, Pau; Toska, Eneda
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 6(2019)
• Publication Date: 2019-11-02
• Subjects: PI3K pathway -- breast cancer -- estrogen receptor -- KMT2D -- chromatin regulation -- PI3K inhibitors -- therapy resistance -- AKT1 -- SGK1; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1625620
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Estrogen Receptor (ER) and the phosphoinositide 3-kinase (PI3K) pathways participate in regulatory crosstalk in breast cancer. We identified that chromatin regulation is at the intersection of oncogenic PI3K and ER. The PI3K effectors AKT, also known as protein kinase B (PKB), and SGK (serum/glucocorticoid-regulated kinase) play a redundant role by phosphorylating the chromatin regulator KMT2D and modulating ER activity and therapy resistance.