Structure and function of a monocarboxylate transporter homolog specific for L-lactate. (2nd November 2019)

• Record Type: Journal Article
• Authors: Bosshart, Patrick D.; Kalbermatter, David; Bonetti, Sara; Fotiadis, Dimitrios
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 6(2019)
• Publication Date: 2019-11-02
• Subjects: L-lactate transporter -- monocarboxylate transporter -- SLC16 family -- structure -- transport mechanism; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1646605
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L -lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure–function analysis provides insights into the molecular working mechanisms of ligand binding and L -lactate transport.