Isolation and structure determination of a new indene derivative from endophytic fungus Aspergillus flavipes Y-62. Issue 20 (18th October 2019)

• Record Type: Journal Article
• Authors: Akhter, Najeeb; Pan, Chengqian; Liu, Yanqin; Shi, Yutong; Wu, Bin
• Is Part Of: Natural product research. Volume 33:Issue 20(2019)
• Page Start: 2939
• Page End: 2944
• Publication Date: 2019-10-18
• Subjects: Endophytic fungi -- Indene derivative -- secondary metabolites -- Antimicrobial activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1510399
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: As part of the search for naturally derived secondary metabolites, a novel indene derivative, compound 1, together with nine known metabolites (2 –10 ) have been purified from an ethyl acetate extract of the plant-associated fungus Aspergillus flavipes Y-62, isolated from Suaeda glauca (Bunge) Bunge which was collected along Zhoushan coast, Zhejiang province, East China. The structure of the new compound 1 was elucidated by extensive use of spectroscopic techniques like 1D, 2D NMR, and HR-TOF-MS, while the known metabolites were established based on both spectral methods as well as by comparison with the previous literature. Compound 1 exhibited antimicrobial activities against the gram-negative pathogen Pseudomonas aeruginosa and Klebsiella pneumoniae with equal MIC values of 32 µg/ml. Abstract :