Tumor suppression by control of matrix metalloproteinase recycling. (2nd November 2019)

• Record Type: Journal Article
• Authors: Sneeggen, Marte; Schink, Kay O.; Stenmark, Harald
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 6(2019)
• Publication Date: 2019-11-02
• Subjects: Endocytosis -- invasion -- metalloproteinase -- metastasis -- tumor suppressor; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1646606
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Secretion of matrix metalloproteinases (MMPs) enables cancer cells to degrade extracellular matrix, thus promoting tumor invasion and metastasis. We have recently found that the endosomal protein WDFY2 serves as a gatekeeper for MMP recycling from endosomes and that deletion of WDFY2, which is frequently lost in metastatic cancers, causes increased matrix degradation and cell invasion.