Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer. (2nd January 2020)
- Record Type:
- Journal Article
- Title:
- Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer. (2nd January 2020)
- Main Title:
- Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer
- Authors:
- Musa, Julian
Grünewald, Thomas G. P. - Abstract:
- ABSTRACT: Deciphering principles of inter-tumoral heterogeneity is crucial for refinement of precision oncology. We have recently demonstrated that 'oncogenic cooperation' between somatic mutations and regulatory germline variants can serve as a major cause for inter-tumoral heterogeneity, suggesting the requirement of integrating the regulatory genome into 'omics'-based precision oncology.
- Is Part Of:
- Molecular & cellular oncology. Volume 7:Number 1(2020)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 7:Number 1(2020)
- Issue Display:
- Volume 7, Issue 1 (2020)
- Year:
- 2020
- Volume:
- 7
- Issue:
- 1
- Issue Sort Value:
- 2020-0007-0001-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-01-02
- Subjects:
- Oncogenic cooperation -- Ewing sarcoma -- MYBL2 -- B-MYB -- cancer -- CDK2 inhibitors -- EWSR1-FLI1 -- clinical outcome -- predictive biomarker
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2019.1682924 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 12709.xml