A computational model to predict cell traction-mediated prestretch in the mitral valve. Issue 15 (18th November 2019)

• Record Type: Journal Article
• Authors: van Kelle, M. A. J.; Rausch, M. K.; Kuhl, E.; Loerakker, S.
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 22:Issue 15(2019)
• Page Start: 1174
• Page End: 1185
• Publication Date: 2019-11-18
• Subjects: Prestretch -- mitral valve -- cell-traction forces -- finite element method; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; Biomechanics -- Periodicals; Biomedical Engineering -- methods -- Periodicals; Computing Methodologies -- Periodicals; 612.7
• DOI: 10.1080/10255842.2019.1647533
• Languages: English
• ISSNs: 1025-5842

Abstract

Abstract: Prestretch is observed in many soft biological tissues, directly influencing the mechanical behavior of the tissue in question. The development of this prestretch occurs through complex growth and remodeling phenomena, which yet remain to be elucidated. In the present study it was investigated whether local cell-mediated traction forces can explain the development of global anisotropic tissue prestretch in the mitral valve. Towards this end, a model predicting actin stress fiber-generated traction forces was implemented in a finite element framework of the mitral valve. The overall predicted magnitude of prestretch induced valvular contraction after release of in vivo boundary constraints was in good agreement with data reported on valvular retraction after excision from the heart. Next, by using a systematic variation of model parameters and structural properties, a more anisotropic prestretch development in the valve could be obtained, which was also similar to physiological values. In conclusion, this study shows that cell-generated traction forces could explain prestretch magnitude and anisotropy in the mitral valve.