1H-NMR Analysis of Metabolic Changes Induced by Snf1/AMP-Activated Protein Kinase During Environmental Stress Responses. Issue 3 (3rd July 2019)

• Record Type: Journal Article
• Authors: Kim, Jiyoung; Oh, Junsang; Yoon, Deok-Hyo; Sung, Gi-Ho
• Is Part Of: Mycobiology. Volume 47:Issue 3(2019)
• Page Start: 346
• Page End: 349
• Publication Date: 2019-07-03
• Subjects: Snf1/AMPK -- stress signals -- nuclear magnetic resonance -- metabolic changes -- yeast; Mycology -- Periodicals; Mycology -- Korea -- Periodicals; Fungi -- Periodicals; Fungi -- Korea -- Periodicals; Fungi; Mycology; Korea; Mycology -- Periodicals; Fungi -- Periodicals; Periodicals; Electronic journals; 579.5
• DOI: 10.1080/12298093.2019.1625854
• Languages: English
• ISSNs: 1229-8093

Abstract

Abstract: AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress such as salt stress. Snf1 regulates metabolic enzymes such as acetyl-CoA carboxylase, indicating a possible role for Snf1 in metabolic regulation. In this article, we performed nuclear magnetic resonance (NMR) spectroscopy to profile the metabolic changes induced by Snf1 under environmental stress. According to our NMR data, we suggest that Snf1 plays a role in regulating cellular concentrations of a variety of metabolites during environmental stress responses.