Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates. (2nd January 2020)

• Record Type: Journal Article
• Authors: Taskin, Asli Aras; Poveda-Huertes, Daniel; Vögtle, F.-Nora
• Is Part Of: Molecular & cellular oncology. Volume 7:Number 1(2020)
• Publication Date: 2020-01-02
• Subjects: Mitochondria-to-nucleus communication -- dual targeting -- mitochondrial proteostasis -- protein biogenesis -- mitochondrial unfolded protein response; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1698256
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression.