The Usefulness of Aqueous Fluid Analysis for Epstein–Barr Virus in Patients with Uveitis. (2nd January 2020)

• Record Type: Journal Article
• Authors: Groen-Hakan, F.; Van Der Eijk, A.A.; Rothova, A.
• Is Part Of: Ocular immunology and inflammation. Volume 28:Number 1(2020)
• Page Start: 126
• Page End: 132
• Publication Date: 2020-01-02
• Subjects: Aqueous fluid analysis -- clinical picture -- Epstein–Barr virus -- uveitis -- visual prognosis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2018.1543709
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To determine characteristics of patients with laboratory findings indicative of intraocular Epstein–Barr-virus (EBV) infection and to establish the usefulness of the laboratory analysis in patients with uveitis. Methods : Retrospective study of patients who underwent diagnostic aqueous fluid analysis. Diverse demographic data of patients were registered. Results : EBV-PCR tested positive in 3/201 (1%) and EBV-GWC in 22/245 (9%). The prevalence of immunosuppression was similar in EBV positive (by PCR/GWC) and EBV negative patients (7/25; 28% vs. 50/272;18%, P = 0.29). Out of all 22 EBV-GWC positive patients, GWC was between 3 and 10 in 91%. In total, 14 patients had laboratory results indicating only EBV infection. Patients without an alternative explanation for uveitis (6/14; 43%) had a chronic recurrent course and good visual prognosis. Conclusion : Low EBV-GWC values combined with multiple positive GWC and/or PCR for other infectious agents. Intraocular assessment for EBV in the initial examination of uveitis patients has limited value.