Physical activity in COPD: Minimal clinically important difference for medical events. (17th December 2018)

• Record Type: Journal Article
• Authors: Teylan, Merilee; Kantorowski, Ana; Homsy, Diana; Kadri, Reema; Richardson, Caroline; Moy, Marilyn
• Is Part Of: Chronic respiratory disease. Volume 16(2019)
• Publication Date: 2018-12-17
• Subjects: Anchor-based method -- daily step count -- exercise -- physical activity -- COPD; Respiratory organs -- Diseases -- Periodicals; 616.2005
• DOI: 10.1177/1479973118816424
• Languages: English
• ISSNs: 1479-9723

Abstract

Estimates of the minimal clinically important difference (MCID) for physical activity (PA) in chronic obstructive pulmonary disease (COPD) are needed. The objective is to provide an anchor-based estimate of the MCID for daily step count. PA was promoted in persons with COPD using a pedometer (Omron HJ-720ITC) alone or a pedometer plus interactive website for 3 months. Participants wore the pedometer daily and received phone calls monthly to ascertain medical events. Medical events were counted when a participant self-reported that he/she had (1) worsening of breathing, (2) change to breathing medications, (3) medical care from an emergency room for any reason, or (4) hospitalization for any reason. Generalized linear regression models assessed daily step count as change at the end of study and averaged over the 15, 31, or 61 days centered on the event, in those with an event compared to those without one. All categories of events carried equal weight in the analyses. We studied 93 persons, 46 of whom had an event. Participants who experienced an event had a decrease of 1086 (95% confidence interval (CI): −2124 to −48) or 887 (95% CI: −2030 to 257) steps/day in the pedometer plus website or pedometer alone groups, respectively, compared to those without one. In the days centered on an event, participants who had an event experienced a decrease of 882–983 steps/day (pedometer plus website) or a decrease of 351–495 steps/day (pedometer alone), compared to those without one. The MCID for PA in COPD ranges from 350 steps/day to 1100 steps/day.