Harnessing diverse transcriptional regulators for natural product discovery in fungi. Issue 1 (29th April 2019)

• Record Type: Journal Article
• Authors: Lyu, Hai-Ning; Liu, Hong-Wei; Keller, Nancy P.; Yin, Wen-Bing
• Is Part Of: Natural product reports. Volume 37:Issue 1(2020)
• Page Start: 6
• Page End: 16
• Publication Date: 2019-04-29
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c8np00027a
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : This review covers diverse transcriptional regulators for the activation of secondary metabolism and novel natural product discovery in fungi. Abstract : Covering: Up to March 2019 Secondary metabolites (SMs) are chemical entities produced by organisms in response to environmental stimuli and as a defense against biological warfare. The production of SMs is controlled by a hierarchical regulatory network involving core factors that orchestrate transcriptional activation of SM gene clusters. In the past few years, significant achievements have been made in the discovery of novel fungal natural products by genetic manipulations of various types of transcriptional regulators. In this review, we summarized the representative regulators for the activation of fungal secondary metabolism and focused on the strategies for the exploitation of these regulators and their application in finding novel structures.