Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions. Issue 1 (10th July 2019)

• Record Type: Journal Article
• Authors: Jin, Wen-Bing; Wu, Sheng; Xu, Yi-Fan; Yuan, Hua; Tang, Gong-Li
• Is Part Of: Natural product reports. Volume 37:Issue 1(2020)
• Page Start: 17
• Page End: 28
• Publication Date: 2019-07-10
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c9np00032a
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : HemN-like radical S -adenosyl-l -methionine (SAM) enzymes have been recently disclosed to catalyze diverse chemically challenging reactions from primary to secondary metabolic pathways. Abstract : Covering: 2012 to 2019 HemN-like radical S -adenosyl-l -methionine (SAM) enzymes have been recently disclosed to catalyze diverse chemically challenging reactions from primary to secondary metabolic pathways. In this highlight, we summarize the reaction examples catalyzed by HemN-like enzymes to date and the enzymatic mechanisms reported. From the recent mechanistic investigations, we reason that there is a shared initiating mechanism wherein a characteristic SAM methylene radical is proposed to abstract a hydrogen atom from an sp 3 carbon or add onto an sp 2 carbon center although variations occur thereafter from reaction to reaction, as well as providing a brief insight into some future prospects.