A PLAG1 mutation contributed to stature recovery in modern cattle. Issue 1 (December 2017)

• Record Type: Journal Article
• Authors: Utsunomiya, Yuri; Milanesi, Marco; Utsunomiya, Adam; Torrecilha, Rafaela; Kim, Eui-Soo; Costa, Márcio; Aguiar, Tamíris; Schroeder, Steven; Carmo, Adriana; Carvalheiro, Roberto; Neves, Haroldo; Padula, Romulo; Sussai, Thayla; Zavarez, Ludmilla; Cipriano, Rafael; Caminhas, Maria; Hambrecht, George; Colli, Licia; Eufemi, Elisa; Ajmone-Marsan, Paolo; Cesana, Deneb; Sannazaro, Marco; Buora, Maurizio; Morgante, Michele; Liu, George; Bickhart, Derek; Van Tassell, Curtis; Sölkner, Johann; Sonstegard, Tad; Garcia, José
• Is Part Of: Scientific reports. Volume 7:Issue 1(2017)
• Page Start: 1
• Page End: 15
• Publication Date: 2017-12
• Subjects: Natural history -- Research -- Periodicals; Biology -- Research -- Periodicals; Physical sciences -- Research -- Periodicals; Earth sciences -- Research -- Periodicals; Environmental sciences -- Research -- Periodicals; 502.85
• DOI: 10.1038/s41598-017-17127-1
• Languages: English
• ISSNs: 2045-2322

Abstract

Abstract The recent evolution of cattle is marked by fluctuations in body size. Height in theBos taurus lineage was reduced by a factor of ~1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovinePLAG1 mutation (Q ) with major effects on body size, weight and reproduction is a >1, 000 years old derived allele that increased rapidly in frequency in Northwestern EuropeanB. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-EuropeanB. taurus andBos indicus breeds. These data implicate a major role ofQ in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.