Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas. Issue 5 (24th December 2019)

• Record Type: Journal Article
• Authors: Subiros-Funosas, Ramon; Ho, Vivian Cheuk Lam; Barth, Nicole D.; Mendive-Tapia, Lorena; Pappalardo, Morena; Barril, Xavier; Ma, Ruoyu; Zhang, Cheng-Bin; Qian, Bin-Zhi; Sintes, Miquel; Ghashghaei, Ouldouz; Lavilla, Rodolfo; Vendrell, Marc
• Is Part Of: Chemical science. Volume 11:Issue 5(2020)
• Page Start: 1368
• Page End: 1374
• Publication Date: 2019-12-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc05558d
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Trp(redBODIPY) is the first red-emitting Trp-based amino acid for the preparation of fluorogenic peptides with retention of target binding affinity. Abstract : Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.