Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis. Issue 12 (December 2018)

• Record Type: Journal Article
• Authors: Zhang, Qiangzhe; Dehaini, Diana; Zhang, Yue; Zhou, Julia; Chen, Xiangyu; Zhang, Lifen; Fang, Ronnie; Gao, Weiwei; Zhang, Liangfang
• Is Part Of: Nature nanotechnology. Volume 13:Issue 12(2018:Dec.)
• Page Start: 1182
• Page End: 1190
• Publication Date: 2018-12
• Subjects: Nanotechnology -- Periodicals; 620.505
• DOI: 10.1038/s41565-018-0254-4
• Languages: English
• ISSNs: 1748-3387

Abstract

Abstract Rheumatoid arthritis is a common chronic inflammatory disorder and a major cause of disability. Despite the progress made with recent clinical use of anti-cytokine biologics, the response rate of rheumatoid arthritis treatment remains unsatisfactory, owing largely to the complexity of cytokine interactions and the multiplicity of cytokine targets. Here, we show a nanoparticle-based broad-spectrum anti-inflammatory strategy for rheumatoid arthritis management. By fusing neutrophil membrane onto polymeric cores, we prepare neutrophil membrane-coated nanoparticles that inherit the antigenic exterior and associated membrane functions of the source cells, which makes them ideal decoys of neutrophil-targeted biological molecules. It is shown that these nanoparticles can neutralize proinflammatory cytokines, suppress synovial inflammation, target deep into the cartilage matrix, and provide strong chondroprotection against joint damage. In a mouse model of collagen-induced arthritis and a human transgenic mouse model of arthritis, the neutrophil membrane-coated nanoparticles show significant therapeutic efficacy by ameliorating joint damage and suppressing overall arthritis severity. Neutrophil membrane-coated nanoparticles reduce neutrophil-mediated inflammation in animal models of rheumatoid arthritis by acting as decoy devices and interacting with immunoregulatory agents targeted towards these cells.