A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy. Issue 7 (24th December 2019)

• Record Type: Journal Article
• Authors: Zhou, Yimin; Wong, Roy C. H.; Dai, Gaole; Ng, Dennis K. P.
• Is Part Of: Chemical communications. Volume 56:Issue 7(2020)
• Page Start: 1078
• Page End: 1081
• Publication Date: 2019-12-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc07938f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Inverse-electron-demand Diels–Alder reaction of a 1, 2, 4, 5-tetrazine-substituted boron dipyrromethene with a biotin-conjugated trans -cyclooctene results in site-specific activation of the photoactivity of the former photosensitiser. Abstract : A boron dipyrromethene based photosensitiser substituted with a 1, 2, 4, 5-tetrazine moiety has been prepared of which the photoactivity can be activated upon an inverse-electron-demand Diels–Alder reaction with trans -cyclooctene derivatives. By using a biotin-conjugated trans -cyclooctene to tag the biotin-receptor-positive HeLa cells, this photosensitiser exhibits site-specific activation through cycloaddition, leading to high photocytotoxicity.