Genetic engineering in nonhuman primates for human disease modeling. Issue 2 (February 2018)

• Record Type: Journal Article
• Authors: Sato, Kenya; Sasaki, Erika
• Is Part Of: Journal of human genetics. Volume 63:Issue 2(2018)
• Page Start: 125
• Page End: 131
• Publication Date: 2018-02
• Subjects: Medical genetics -- Periodicals; Human genetics -- Periodicals; 616.042
• DOI: 10.1038/s10038-017-0351-5
• Languages: English
• ISSNs: 1434-5161

Abstract

Abstract Nonhuman primate (NHP) experimental models have contributed greatly to human health research by assessing the safety and efficacy of newly developed drugs, due to their physiological and anatomical similarities to humans. To generate NHP disease models, drug-inducible methods, and surgical treatment methods have been employed. Recent developments in genetic and developmental engineering in NHPs offer new options for producing genetically modified disease models. Moreover, in recent years, genome-editing technology has emerged to further promote this trend and the generation of disease model NHPs has entered a new era. In this review, we summarize the generation of conventional disease model NHPs and discuss new solutions to the problem of mosaicism in genome-editing technology.