Evolution of empiric vancomycin dosing in a neonatal population. (December 2018)

• Record Type: Journal Article
• Authors: Radu, Luiza; Bengry, Tanner; Akierman, Albert; Alshaikh, Belal; Yusuf, Kamran; Dersch-Mills, Deonne
• Is Part Of: Journal of perinatology. Volume 38:Number 12(2018)
• Page Start: 1702
• Page End: 1707
• Publication Date: 2018-12
• Subjects: Perinatology -- Periodicals; 618.32005
• DOI: 10.1038/s41372-018-0251-3
• Languages: English
• ISSNs: 0743-8346

Abstract

Abstract Background In 2014, we assessed the effectiveness of our neonatal vancomycin empirical dosing regimen (15–45 mg/kg/day) which led to development of a revised regimen (20–60 mg/kg/day). Objective To validate the revised empirical vancomycin dosage regimen in achieving target troughs. Methods The primary outcome of this multicenter retrospective before-and-after cohort study was the proportion of neonates in the present cohort achieving trough levels below, at or above target (<10, 10–20 and >20 mg/L). Secondary outcomes included difference between cohorts (historical and present) in mean troughs and proportion of patients achieving target levels. Results Out of 118 participants, 63 (53.39%) achieved target troughs, 44 (37.29%) had below target troughs and 11 (9.32%) reached above target levels. Mean trough levels and proportion of patients achieving target levels were higher in the present versus historical cohort (p < 0.01 for all comparisons). Conclusions The revised empiric dosing regimen was more effective in achieving target serum trough concentrations.