Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. Issue Volume 48:Issue D1(2020) (6th November 2019)

• Record Type: Journal Article
• Authors: Wang, Yunxia; Zhang, Song; Li, Fengcheng; Zhou, Ying; Zhang, Ying; Wang, Zhengwen; Zhang, Runyuan; Zhu, Jiang; Ren, Yuxiang; Tan, Ying; Qin, Chu; Li, Yinghong; Li, Xiaoxu; Chen, Yuzong; Zhu, Feng
• Is Part Of: Nucleic acids research. Volume 48:Issue D1(2020)
• Page Start: D1031
• Page End: D1041
• Publication Date: 2019-11-06
• Subjects: Nucleic acids -- Periodicals; Molecular biology -- Periodicals; 572.805
• DOI: 10.1093/nar/gkz981
• Languages: English
• ISSNs: 0305-1048

Abstract

Abstract: Knowledge of therapeutic targets and early drug candidates is useful for improved drug discovery. In particular, information about target regulators and the patented therapeutic agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, and the development of drug discovery tools. To complement other databases, we constructed the Therapeutic Target Database (TTD) with expanded information about (i) target-regulating microRNAs and transcription factors, (ii) target-interacting proteins, and (iii) patented agents and their targets (structures and experimental activity values if available), which can be conveniently retrieved and is further enriched with regulatory mechanisms or biochemical classes. We also updated the TTD with the recently released International Classification of Diseases ICD-11 codes and additional sets of successful, clinical trial, and literature-reported targets that emerged since the last update. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp . In case of possible web connectivity issues, two mirror sites of TTD are also constructed (http://db.idrblab.org/ttd/ and http://db.idrblab.net/ttd/ ).