Flow Diversion for Intracranial Aneurysm Treatment: Trials Involving Flow Diverters and Long-Term Outcomes. (16th December 2019)

• Record Type: Journal Article
• Authors: Chancellor, Bree; Raz, Eytan; Shapiro, Maksim; Tanweer, Omar; Nossek, Erez; Riina, Howard A; Nelson, Peter Kim
• Is Part Of: Neurosurgery. Volume 86(2020)Supplement 1
• Page Start: S36
• Page End: S45
• Publication Date: 2019-12-16
• Subjects: Aneurysm -- Flow diversion -- FRED -- PED -- Pipeline -- SILK -- Surpass; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyz345
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: Flow diverters (FDs) have changed the management of brain aneurysms; not only for complex aneurysms (giant, fusiform and blister) refractory to conventional therapies, but also for unruptured lesions previously managed by traditional surgical or coil-based endovascular methods. Since 2011 when the Pipeline TM Embolization Device (Medtronic) was cleared by the Food and Drug Administration for adults with large or giant wide-neck intracranial aneurysms of the internal carotid artery proximal to the posterior communicating segment, the role of flow diversion for aneurysm treatment has expanded—supported by favorably low complication and high cure rates compared with alternative treatments. Here we review the key clinical trials and the long term outcomes that have demonstrated safety and efficacy of minimized porosity endoluminal devices in the treatment of cerebral aneurysms.