Does Extended Pre Quit Bupropion Aid in Extinguishing Smoking Behavior?. Issue 11 (14th January 2015)
- Record Type:
- Journal Article
- Title:
- Does Extended Pre Quit Bupropion Aid in Extinguishing Smoking Behavior?. Issue 11 (14th January 2015)
- Main Title:
- Does Extended Pre Quit Bupropion Aid in Extinguishing Smoking Behavior?
- Authors:
- Hawk, Larry W.
Ashare, Rebecca L.
Rhodes, Jessica D.
Oliver, Jason A.
Cummings, Kenneth Michael
Mahoney, Martin C. - Abstract:
- Abstract : Introduction: Understanding the mechanisms by which bupropion promotes smoking cessation may lead to more effective treatment. To the extent that reduced smoking reinforcement is one such mechanism, a longer duration of pre quit bupropion treatment should promote extinction of smoking behavior. We evaluated whether 4 weeks of pre quit bupropion (extended run-in) results in greater pre quit reductions in smoking rate and cotinine and, secondarily, greater short-term abstinence, than standard 1 week of pre quit bupropion (standard run-in). Methods: Adult smokers ( n = 95; 48 females) were randomized to a standard run-in group ( n = 48; 3-week placebo, then 1-week bupropion pre quit) or an extended run-in group (4-week pre quit bupropion; n = 47). Both groups received group behavioral counseling and 7 weeks of post quit bupropion. Smoking rate (and craving, withdrawal, and subjective effects) was collected daily during the pre quit period; biochemical data (cotinine and carbon monoxide) were collected at study visits. Results: During the pre quit period, the extended run-in group exhibited a greater decrease in smoking rate, compared to the standard run-in group, interaction p = .03. Cigarette craving and salivary cotinine followed a similar pattern, though the latter was evident only among women. Biochemically verified 4-week continuous abstinence rates were higher in the extended run-in group (53%) than the standard run-in group (31%), p = .033. Conclusions: TheAbstract : Introduction: Understanding the mechanisms by which bupropion promotes smoking cessation may lead to more effective treatment. To the extent that reduced smoking reinforcement is one such mechanism, a longer duration of pre quit bupropion treatment should promote extinction of smoking behavior. We evaluated whether 4 weeks of pre quit bupropion (extended run-in) results in greater pre quit reductions in smoking rate and cotinine and, secondarily, greater short-term abstinence, than standard 1 week of pre quit bupropion (standard run-in). Methods: Adult smokers ( n = 95; 48 females) were randomized to a standard run-in group ( n = 48; 3-week placebo, then 1-week bupropion pre quit) or an extended run-in group (4-week pre quit bupropion; n = 47). Both groups received group behavioral counseling and 7 weeks of post quit bupropion. Smoking rate (and craving, withdrawal, and subjective effects) was collected daily during the pre quit period; biochemical data (cotinine and carbon monoxide) were collected at study visits. Results: During the pre quit period, the extended run-in group exhibited a greater decrease in smoking rate, compared to the standard run-in group, interaction p = .03. Cigarette craving and salivary cotinine followed a similar pattern, though the latter was evident only among women. Biochemically verified 4-week continuous abstinence rates were higher in the extended run-in group (53%) than the standard run-in group (31%), p = .033. Conclusions: The extended use of bupropion prior to a quit attempt reduces smoking behavior during the pre quit period and improved short-term abstinence rates. The data are consistent with an extinction-of-reinforcement model and support further investigation of extended run-in bupropion therapy for smoking cessation. … (more)
- Is Part Of:
- Nicotine & tobacco research. Volume 17:Issue 11(2015:Nov.)
- Journal:
- Nicotine & tobacco research
- Issue:
- Volume 17:Issue 11(2015:Nov.)
- Issue Display:
- Volume 17, Issue 11 (2015)
- Year:
- 2015
- Volume:
- 17
- Issue:
- 11
- Issue Sort Value:
- 2015-0017-0011-0000
- Page Start:
- 1377
- Page End:
- 1384
- Publication Date:
- 2015-01-14
- Subjects:
- Nicotine -- Periodicals
Tobacco -- Research -- Periodicals
Tobacco habit -- Periodicals
Nicotine -- Periodicals
Tobacco -- Periodicals
Smoking -- Periodicals
613.85 - Journal URLs:
- http://journalsonline.tandf.co.uk/app/home/journal.asp?wasp=94a708f2c2dd42cb9f0841fff9268622&referrer=parent&backto=searchpublicationsresults, 1, 1;homemain, 1, 1; ↗
http://ukcatalogue.oup.com/ ↗ - DOI:
- 10.1093/ntr/ntu347 ↗
- Languages:
- English
- ISSNs:
- 1462-2203
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6110.106500
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 12686.xml