The heat's on: nuclear stress bodies signal intron retention. (9th January 2020)

• Record Type: Journal Article
• Authors: Erhardt, Sylvia; Stoecklin, Georg
• Is Part Of: EMBO journal. Volume 39:Number 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-09
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2019104154
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : The cellular response to heat shock requires massive adaptation of gene expression driven by the transcription factor HSF1, which assembles in nuclear stress bodies together with human satellite III RNA and numerous splicing factors. In this issue of The EMBO Journal, Ninomiya et al demonstrate that nuclear stress bodies serve as a platform for phosphorylation of the SR protein SRSF9 by the CLK1 kinase, which promotes retention of a large number of introns during the recovery phase from heat shock. Abstract : A new study reveals that nuclear stress bodies serve as a platform for SR protein phosphorylation, thereby altering splicing of sequestered mRNAs during the recovery from heat shock.