A RuII Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy. Issue 7 (28th January 2020)

• Record Type: Journal Article
• Authors: Hu, Xiaochun; Lu, Yonglin; Dong, Chunyan; Zhao, Wenrong; Wu, Xuewen; Zhou, Lulu; Chen, Lv; Yao, Tianming; Shi, Shuo
• Is Part Of: Chemistry. Volume 26:Issue 7(2020)
• Page Start: 1668
• Page End: 1675
• Publication Date: 2020-01-28
• Subjects: click reactions -- drug delivery -- multimodal cancer treatment -- nanoplatforms -- RuII polypyridyl complexes; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201904704
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Despite drug delivery nanoplatforms receiving extensive attention, development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. Herein, a versatile nanoplatform based on a zirconium framework (UiO‐66‐N3 ) was synthesized, which demonstrated a combined photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT) for cancer treatment. A Ru II polypyridyl alkyne complex (Ra) as a photosensitizer was modified into a nanoplatform by click reactions for the first time. When exposed to suitable light irradiation, the as‐prepared multifunctional nanoplatform (UiO‐Ra‐DOX‐CuS) not only demonstrated efficient 1 O2 generation, but also exhibited excellent photothermal conversion ability. In particular, the nanotherapeutic agent presented a dual‐stimuli response; either acidic environment or NIR laser irradiation would trigger the drug release. The synergetic efficacy of UiO‐Ra‐DOX‐CuS combined PDT, PTT, and CT, which was evaluated by cell experiments. Moreover, the design could promote the development of Ru II polypyridyl alkyne complexes based multifunctional nanoparticles and multimodal cancer treatment. Abstract : Combined photodynamic/photothermal/chemotherapy : A Ru II polypyridyl alkyne complex (Ra) is reported as a photosensitizer, which was modified into metal–organic frameworks (MOFs) by click reactions for the first time. In addition, a new way to integrate chemo‐photodynamic‐photothermal therapy and dual‐stimuli response release into one nanoplatform is presented.