Simultaneous detection of cerebral blood perfusion and cerebral edema using swept‐source optical coherence tomography. Issue 2 (24th November 2019)

• Record Type: Journal Article
• Authors: Liu, Jian; Li, Yan; Yu, Yao; Yuan, Xincheng; Lv, Hongyu; Liu, Lanxiang; Zhao, Yuqian; Wang, Yi; Ma, Zhenhe
• Is Part Of: Journal of biophotonics. Volume 13:Issue 2(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-11-24
• Subjects: cerebral blood perfusion -- cerebral edema -- middle cerebral artery occlusion -- optical attenuation coefficient -- swept‐source optical coherence tomography; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201960087
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract: The progression of ischemic cerebral edema (CE) is closely related to the level of cerebral blood perfusion (CBP) and affects each other. Simultaneous detection of CBP and CE is helpful in understanding the mechanisms of ischemic CE development. In this article, a wide field of view swept‐source optical coherence tomography system was used to detect CE status and CBP levels simultaneously in middle cerebral artery occlusion rats. Images reflecting these two physiological states can be reconstructed with only one C‐scan. We quantify these two physiological states into four parameters, which contain two vascular parameters (vascular displacement distance and vascular perfusion density) and two edema parameters (optical attenuation coefficient and edema area). The association between the two vascular parameters and the two edema parameters was analyzed. The results show that there is a strong linear relationship between blood flow parameters and edema parameters. This work provides a new option for CE in vivo detection, and is very likely to play an important role in the development of relevant drugs or in selection of treatment options. Abstract : In this article, a wide field of view swept‐source optical coherence tomography system was used to detect cerebral edema status and cerebral blood perfusion levels simultaneously in middle cerebral artery occlusion rats. Images reflecting these two physiological states can be reconstructed with only one C‐scan. We quantify these two physiological states into four parameters, which contain two vascular parameters and two edema parameters. The association between the two vascular parameters and the two edema parameters was analyzed. The results show that there is a strong linear relationship between blood flow parameters and edema parameters.