Palladium-catalyzed tandem oxidative annulation of α-amino ketones leading to 2-aroylindoles. Issue 7 (14th February 2020)

• Record Type: Journal Article
• Authors: Jiang, Tao-Shan; Dai, Long; Zhou, Yuhui; Zhang, Xiuli
• Is Part Of: Tetrahedron. Volume 76:Issue 7(2020)
• Publication Date: 2020-02-14
• Subjects: 2-Aroylindoles -- α-Amino ketones -- Palladium-catalyzed -- Oxidative annulations; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2019.130917
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A simple synthesis of 2-aroylindoles via palladium-catalyzed tandem oxidative annulation directly from α-amino ketones has been developed. In this transformation, two-step reaction including oxidation of α-amino aetones to generate imine intermediates and subsequent palladium-catalyzed aerobic annulation to give 2-aroylindoles was compatible in one pot. Graphical abstract: Image 1 Highlights: Efficient synthesis of 2-aroylindoles from α-amino ketones. Palladium-catalyzed tandam oxidative reactions in one pot. Imines are the key intermediates.